Elecsys® CMV panel

Precise diagnosis of acute CMV infections

  • Cytomegalovirus (CMV) - also known as human herpes virus 5 (HHV 5) - is one of the world’s most widespread viruses and is often asymptomatic in healthy individuals
  • Lab diagnosis of CMV infection, either for screening purposes or if a concrete suspicion exists, is based on the detection of specific IgG and IgM antibodies against the virus
  • The age of the infection can be estimated by using the IgG-avidity test
  • The most commonly requested indications are associated with the assessment of congenital risk, blood transfusion and organ transplantation as well as the clinical management of immunocompromised patients
Elecsys CMV IgG test characteristics
Assay time 18 min
Sample material Serum, Li-heparin, K2-EDTA, K3-EDTA, plasma
Sample volume 20 µL
Analytical specificity 96.6 % in 437 potentially cross-reacting samples

Elecsys CMV IgM test characteristics
Assay Time 18 min
Sample Material Serum, Li-heparin, K2-EDTA, K3-EDTA, plasma
Sample Volume 10 µL
Analytical specificity 92.3 % in 413 potentially cross-reacting samples

CMV IgG Avidity test characteristics
Assay time 2 x 18 min (in parallel)
Sample Material Serum, Li-heparin, K2-EDTA, K3-EDTA, plasma
Sample Volume 10 µL
Clinical sensitivity (95 % confidence limit) 96.1 % (89.0-99.2) n=77, diagnostic
93.4 % (86.9-97.3) n=106, pregnant
Clinical specififity (95 % confidence limit) 90.9 % (78.3-97.5) n=44, diagnostic
100.0 % (93.0-100) n=51, pregnant

A reliable solution for the diagnosis and screening of CMV infections

Clinical benefit

  • The CMV tests were designed with an anti-inteference approach in mind
  • The CMV IgM test was designed to detect only the IgM associated with an acute infection
  • Both CMV IgM and CMV IgG tests include an anti-interferent agent to prevent cross reactivity with other herpes viruses

Benefit for the lab

  • Low sample volume needed (only 10 µL for IgM and 20 µL for IgG)
  • Short assay time: 18 minutes
  • Anti-interference design ensures only relevant positive cases are identified - reducing unnecessary repeat testing

Clinical evaluation of new automated cytomegalovirus IgM and IgG assays for the Elecsys® analyser platform:
Revello, M.G., Vauloup-Fellous, C., Grangeot-Keros, L., van Helden, J., Dickstein. Y., Lipkin, I., Mühlbacher, A., Lazzarotto, T. (2012). Eur J Clin Microbiol Infect Dis Aug 1.

Detection of human cytomegalovirus IgG antibody using automated immunoassay with recombinant antigens gives uniform results to established assays using whole virus antigens:
Baalawi, F., Robertson, P., and Rawlinson, W.D. (2010). Pathology 42(6), 578–580

Comparison of 3 different assays for cytomegalovirus antibody detection
Mühlbacher, A., Mayersbach, P., Schennach, H. (2009). Euromedlab, Innsbruck, Austria. Clinical Chemistry and Laboratory Medicine (June 2009), Volume 47, S234–S247, M-C054