Elecsys® BRAHMS PCT
Elecsys® BRAHMS Procalcitonin (PCT) delivers fully automated, reliable, realtime clinical decision support for the management of sepsis.
PCT is a biomarker with high specificity for an inflammatory response to a bacterial infection. PCT concentrations in the blood can aid clinicians in the detection of clinically relevant bacterial infections. PCT is considered a prognostic marker to support outcome prediction in sepsis patients.1,2,3,4
Sepsis is life threatening organ dysfunction caused by a dysregulated host response to infection.5,6,7 Sepsis and septic shock are major healthcare problems, with more than 1 in 1000 people in developed countries suffering from sepsis each year.8 Early identification and appropriate management in the initial hours after sepsis develops improves outcomes.9
|Assay time||18 min.|
|Sample material||Serum collected using standard sampling tubes or tubes containing separating gel. Liheparin, K3‑EDTA plasma.|
|Sample volume||30 μL|
|Analytical Sensitivity||<0.02 ng/mL|
|Functional Sensitivity||<0.06 ng/mL|
|Traceabilty||Standardized against BRAHMS PCT LIA|
|Measuring range||0.02-100 ng/mL (defined by the lower detection limit and the maximum of the master curve)|
Elecsys BRAHMS PCT helps to improve your sepsis patient management by providing reliable realtime clinical decision support data about a suspected infection, disease severity, and response to treatment.
1 Clec’h C, Ferriere F, Karoubi P, et al. Diagnostic and prognostic value of procalcitonin in patients with septic shock. Crit Care Med. 2004;32(5):11661169.
2 Novotny A, Emmanuel K, Matevossian E, et al. Use of procalcitonin for early prediction of lethal outcome of postoperative sepsis. The American Journal of Surgery 2007;194:3539.
3 Hausfater P, Juillien G, MadonnaPy B, et al. Serum procalcitonin measurement as diagnostic and prognostic marker in febrile adult patients presenting to the emergency department. Crit Care. 2007;11(3):6069.
4 Dahaba AA, Hagara B, Fall A, et al. Procalcitonin for early prediction of survival outcome in postoperative critically ill patients with severe sepsis. Br J Anaesth 2006;97:503508.
5 Singer M, Deutschman CS, Seymour CW et al (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis3). JAMA 315(8):801–810
6 ShankarHari M, Phillips GS, Levy ML et al (2016) Developing a new definition and assessing new clinical criteria for septic shock: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis3). JAMA 315(8):775–787
7 Seymour CW, Liu VX, Iwashyna TJ et al (2016) Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis3). JAMA 315(8):762–774
8 Issrah Jawad, et al: "Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality." J Glob Health. 2012 Jun; 2(1): 00404
9 Rhodes Andrew et al (2016) Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med DOI 10.1007/s0013401746836