Elecsys® Syphilis

elecsys-syphilis1

Confidence in all stages of treponemal infection

  • Syphilis is caused by the intracellular Gram-negative spirochete bacterium Treponema pallidum subspecies pallidum
  • In 2012, approximately 12 million new cases of infection were reported.
  • Most people with syphilis are asymptomatic, but if untreated the infection can cause significant complications.
  • Although syphilis is usually transmitted sexually, it can also be transmitted from mother to fetus with an estimated 1.5 million pregnancies affected globally each year. However, if diagnosed in the early stages, syphilis can be successfully treated and congenital syphilis prevented.
  • Syphilis can be transmitted through blood transfusions.
  • Serological tests like the Elecsys Syphilis assay are the method of choice for the reliable detection of Treponema palladium infections.

Featured Article: Syphilis is returning

Assay time
18 min
Test format
Assay detects total IgG and IgM against bacterial TpN15, TpN17, TpN47
Sample material
Serum, Li-heparin, K2- and K3-EDTA, sodium citrate and CPDA plasma
Sample volume
10 uL
Systems
cobas e 411 analyzer, Elecsys ™ 2010 analyzer
cobas e 601/e 602 modules, Modular™ ANALYTICS <E 170>
Clinical specificity
99.93% (n=4579 blood donors)
99.80% (n=3500 unselected routine samples)
99.88% (n=8079)
Analytical specificity
>200 samples containing antibodies against different pathogens showed no cross reactivity

Sample volume comparison

syphilis-chart1 Details view

Assay time comparison

syphilis-chart2 Details view

Source: Data on file

Designed for high sensitivity and specificity

  • High sensitivity and specificity minimizes the probability of missing true positives in all stages of infection

Clear interpretation of results

  • Clear cut-off separation of positive and negative results

Efficient use of sample volume and time

  • Only 10uL testing volume allows to perform all tests using the same sample
  • Result obtained in only 18 minutes

Efficiency for diagnostic use and blood donor screening

  • Fully automated and integrated with other tests in the STD, TORCH and Blood Safety portfolios