cobas m 511 integrated hematology analyzer

cobas m 511

cobas m 511


Introducing the cobas m 511 integrated hematology analyzer

A new era in hematology

Featuring Bloodhound® technology, the cobas m 511 combines a digital morphology analyzer, cell counter and classifier into one streamlined instrument preparing, staining and analyzing microscopy blood slides.

By counting, identifying, isolating and categorizing white blood cells, red blood cells and platelets and finally presenting the digital images of all these cell types on the Viewing Station including a standard CBC and 5 part differential, the cobas m 511 helps medical technologists concentrate on what really matters: Finding and classifying abnormal cells within a patient sample.

The cobas m 511 in motion

Cellular view


Mechanical view


The future leading Bloodhound® technology represents the core intelligence of the cobas m 511, which uses this unique approach to enter the new field of digital hematology.

Bloodhound® technology analyzes the morphology of individual cells and presents the results of the analysis in detailed images for human interaction. Moreover, while medical technologists will continue to have the option of looking at slides under their microscopes, Bloodhound® technology provides cell-by-cell images that, in many cases, may eliminate the need for microscopic review.

As opposed to the typical indirectly measured approaches used in blood analysis today - primarily impedance and flow cytometry - the Bloodhound® technology images individual cells directly. Based on these direct images, the Bloodhound® technology analyzes each cell's morphology, counts it, and then classifies all the cells in the viewing area to provide a CBC, 5-part differential, and reticulocyte count.

Bloodhound® technology
cobas m 511

Slide preparation

Digital cell counting and classification

Digital cell morphology


  • Low sample volume of 30 μl provides complete CBC, differential and digital morphology
  • Unique slide preparation designed to provide consistent distribution of cells supporting cell integrity
  • Digital multi spectral imaging utilized for cell counting and classification

Unique slide preparation designed to provide consistent distribution of cells supporting cell integrity

A consistent volume of blood is printed in a uniform pattern on a slide. The printed slide is then transferred to a staining station where modified Romanowsky stains are applied. Upon staining, the slide is fully prepared for automated digital imaging as the basis for cell counting, classification and digital morphology.

Digital multi spectral imaging utilized for cell counting and classification

Low-magnification multi spectral imaging is first applied to the slide, digitally identifying and counting the RBCs, WBCs and platelets. In addition, randomized locations of 600 – 700 WBCs are recorded for the differential.

Digital multi spectral imaging utilized for cell counting and classification

High-magnification multi spectral imaging is then applied to the slide to perform the digital differential, classifying the WBCs into 5 normal groups. Unclassified cells are flagged and presented for user review.

Algorithms are applied to measure hemoglobin concentration, the MCV and MPV, as well as identify reticulocytes.

Low and high magnification multi spectral imaging and the application of advanced algorithms result in 26 parameters and a full digital gallery of cell morphology.

Integrated System
cobas m 511

Slide preparation

Digital cell counting and classification

Digital cell morphology



  • Fully integrated CBC + Differential, Slide preparation and Digital Morphology
    - Combines quantitative and morphological data

  • 2 touch-points designed to reduce manual steps

  • 6 minutes from sampling to review of cell morphology
Digital hematology
Digital hematology
  • Designed to reduce the need for manual microscope review
  • Intuitive software providing easy access to RBC, WBC and Platelet image galleries
  • Remote functionality of viewing stations designed to expand your network and provide real-time image access
  • Digital archiving and patient history tracking

cobas m 511 analyzer footprint

cobas m 511 analyzer footprint

cobas m 511 analyzer footprint


cobas m 511 analyzer
Height: 142 cm
Width: 107 cm
Depth: 78 cm
Weight: 389 kg

Viewing station
Height: 46 cm
Width: 53 cm
Depth: 18 cm
Weight: 6 kg


Red Blood Cell
  • RBC – Red Blood Cell Count
  • HCT – Hematocrit
  • MCV – Mean Corpuscular Volume
  • RDW – Red Cell Distribution Width
  • RDW–SD – Red Cell Distribution Width – Standard Deviation
  • #NRBC – Nucleated Red Blood Cell Count
  • %NRBC – Nucleated Red Blood Cell Percent


  • Hgb – Hemoglobin Concentration
  • MCH – Mean Corpuscular Hemoglobin
  • MCHC – Mean Corpuscular Hemoglobin Concentration

  • PLT – Platelet Count
  • MPV – Mean Platelet Volume

White Blood Cell
  • WBC – White Blood Cell Count
  • #NEUT – Neutrophil Absolute Count
  • %NEUT – Neutrophil Percent
  • #LYMPH – Lymphocyte Absolute Count
  • %LYMPH – Lymphocyte Percent
  • #MONO – Monocyte Absolute Count
  • %MONO – Monocyte Percent
  • #EOS – Eosinophil Absolute Count
  • %EOS – Eosinophil Percent
  • #BASO – Basophil Absolute Count
  • %BASO – Basophil Percent

  • #Retic – Reticulocyte Count
  • %Retic – Reticulocyte Percent
  • HGB-RET – Reticulocyte Hemoglobin


Quality control

The cobas m 511 integrated hematology analyzer has several quality control features built into the graphical user interface (GUI) software that are designed to help to reduce subjectivity of cell identification and standardize the quality of the results, sample after sample.

Reagent management

The cobas m 511 integrated hematology analyzer uses the unique DigiMAC3 stain pack for a fully automated fix and stain of the microscopy slide and will process 1,000 cycles without replacement.

Due to an internal reservoir, the cobas m 511 integrated hematology analyzer holds enough reserve reagents to process 25 samples after the DigiMAC3 stain pack empties. Using a proprietary “hot swap” process, technicians can quickly change the DigiMAC3 stain pack while the instrument is still processing specimens, decreasing your downtime while increasing your lab’s efficiency.


cobas m 511 analyzer

  • Line voltage: 100 V AC 115 V AC 230 V AC (+/- 10%)
  • Frequency: 50 - 60 Hz, single phase
  • Power consumption: < 1200 W
  • Operating temperature: 18 to 27 °C (65 - 80 °F)
  • Relative humidity: 20 % to 60 % (non-condensing)
  • Altitude above sea level: Up to 1600 m

Viewing station

  • Line voltage: 100 – 240 V AC
  • Frequency: 50 to 60 Hz, single phase
  • Power consumption: < 120 W

Automatic mode
80 sample on-board capacity.

Open port
30 μL blood volume required for full CBC, DIFF and morphology assessment.

STAT mode
Run up to 3 STAT samples at any time.



DigiMAC3 stain pack and DigiMAC3 wash designed for 1,000 cycles.

Slide input
Five cartridges of 100 slides each can be continuously loaded into system.

System manages waste via plumbing disposal and containers.

Slide output
Continuous unloading of processed and flagged sample slides.



Integrated uninterrupted power supply designed for continuous system uptime.

Bloodhound® technology features an integrated Viewing Station that provides medical technologists and hematologists with cell-by-cell viewing access.

Going beyond what would normally be seen in a field-of-view through a microscope, Bloodhound® technology allows to view individual white blood cells (WBCs), red blood cells (RBCs) and platelets on a high resolution display and organizes them into cell specific galleries. It also allows to sort RBCs by size, shape and hemoglobin concentration as well as platelets by size. All cell images from the various galleries can be enlarged to ensure an even closer examination of the cell’s structure and morphology.

Most importantly, the Bloodhound® technology identifies and isolates abnormal white cells from the population of the non-pathological white cells. These are any cells that cannot be classified due to morphologic or abnormal aberrations and require review by the medical technologist or hematologist.

Review Tab

The Overview Screen found on the Viewing Station lists all cases whose results are ready for review by the medical technologist. The laboratory can pre-set the instrument to auto-release normal cases so that this Overview Screen will only include those that are “flagged”.

Patient Results

Results for each case are organized in a comprehensive review screen that provides both CBC and 5-part Differential data and results. Any unclassified cells are shown in the top right of the screen. Review tabs located on the left side of the screen provide access to more detailed WBC, RBC and platelet results, and associated images.

Manual Differential

When the white blood cell tab is accessed, the 5-part differential results provide a gallery of images by cell type. Any unclassified cells are shown individually at the top of the screen.

Cell Classification Process

Classifying unidentified cells of interest is straightforward; simply click on a particular cell to enlarge the image, and then choose the appropriate cell type from a drop-down menu. Classified cells will be sent to the categories that were selected, and grayed images will be retained on the screen to indicate that action has been taken.

Classified Cells

If required and following initial review, samples with abnormal cells can be sent to a supervisor or pathologist for review on a remote screen, or can be re-accessed on the original Viewing Station.

Release Results

Once all unidentified cells have been reclassified, the results for that case can be released into the Lab Information System (LIS).

Platelet Selection

If desired, the particular field-of-view image containing the platelets can be enlarged with a single click of the mouse.

Remote Review

Images available for review on Remote Viewing Stations.

Red Blood Cell Morphology

Red blood cells are assembled into their own gallery for easy review. This gallery can be sorted by cell size and color.

Overview Table

This shows the status of all the QC options. Color-coding represents the status of the most recent control run, while messages in the boxes tally the overall number of warnings or failures. The interval of the last run is also displayed in the bottom right-hand corner for quick reference.

Platelet Morphology

Platelets are also presented in a gallery and sorted by size. Giant platelets and clumps are shown at the top of the screen.

Levi-Jennings Plots

These are sorted by parameter and allow for all levels of controls to be viewed simultaneously for both the current and past lot numbers.