Multiplate® ASA Reagent

Multiplate® ASA Reagent frontview

Multiplate® ASA Reagent

The ASA Reagent (acetylsalicylic acid) is intended for use as quality control in platelet aggregation function testing with whole blood samples on the Multiplate® analyzer. Addition of ASA Reagent to the blood sample leads to reduced aggregation responses in ASPItest and COLtest. Upon addition to the blood sample the platelet cyclooxygenase pathway is blocked and the cyclooxygenase-dependent Multiplate® tests, ASPItest and COLtest are inhibited. This allows the assessment of an abnormal response in these tests.

Background

Acetylsalicylic acid (ASA) is an acetyl derivative of salicylic acid that is a white, crystalline, weakly acidic substance. It is useful in the relief of headache and muscle and joint aches. Acetylsalicylic acid is also effective in reducing fever, inflammation, and swelling and thus has been used for the treatment of rheumatoid arthritis, rheumatic fever, and mild infection. Acetylsalicylic acid produces an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances promotes platelet binding to each other and the injury site of the damaged walls of blood vessels. As a result acetylsalicylic acid is used in the prevention of arterial and venous thrombosis.1

References

References

  1. Martindale, The Extra Pharmacopoeia, 30th ed, p5.